Biophysics, as a distinct discipline, can be traced to a “gang of four”: Emil du Bois-Reymond, Ernst von Brücke, Hermann von Helmholtz, and Carl Ludwig—all four being physicians and the former three being students of the great German physiologist Johannes Müller, who, in 1847, got together to develop a research program based on the rejection of the, at the time, prevailing notion that living animals depend on special biological laws and vital forces would differ from those that operate in the domain of inorganic nature [1]. It did not quite work out that way and, despite the scientific accomplishments of these four, in particular Helmholtz and Ludwig, the program faltered. In 1892, when Karl Pearson introduced the term “Bio-Physics” in The Grammar of Science to describe the science that links the physical and biological sciences, he also noted “This branch of science does not appear to have advanced very far at present, but it not improbably has an important future.” [2] Biophysics is the study of physical phenomena and physical process in living things, on scales spanning molecules, cells, tissues, and organisms. To use the principles and methods of physics to understand biological systems. It is an interdisciplinary science, closely related to quantitative and systems biology [3].